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KMID : 1024720210110010001
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Geriatric Rehabilitation
2021 Volume.11 No. 1 p.1 ~ p.17
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Senoinflammation as the Underlying Molecular Mechanism of Aging
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Chung Hae-Young
Kim Dae-Hyun
Jung Hee-Jin
Bang Eun-Jin
Ha Su-Gyeong
Noh Sang-Gyun
Lee Ji-Young
Yu Byung-Pal
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Abstract
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Age-related chronic inflammation is characterized as the unresolved low-grade inflammatory process with multi-variable systemic responses, underlying the aging process and various age-related diseases. In this review, we focus on the comprehensive concept of senoinflammation that encompasses age-related inflammation and metabolic dysregulation as well as senescence-associated secretory phenotype in the aging process. In addition, we evaluate biochemical and systems-biological data for the support of the senoinflammation concept and its regulatory process by the anti-aging and anti-inflammatory calorie restriction (CR). Based on observed senoinflammatory occurrences, experimental evidence as well as its modulation by CR, senoinflammation concept is deemed an important framework for elucidation of the molecular mechanisms of the aging process and for the potential therapeutic strategies and targeting anti-aging intervention.
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KEYWORD
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Senoinflammation, Calorie restriction, Anti-aging, Senescence-associated secretory phenotype, Metabolic dysregulation
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